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Global Summit on Stroke

Birmingham, UK

Ying Li

Ying Li

Nanjing Medical University, China

Title: Effect of COC, hypertension, dyslipidemia and susceptibility on the risk of female Stroke in China


Biography: Ying Li


Purpose: To clarify the eff ect of COC, hypertension, dyslipidemia and susceptibility on the risk of female stroke in order to decrease the risk of female stroke in China. Method: Th is was a population-based multicenter case control study. A prospective cohort study was undertaken in 25 towns in two counties in Jiangsu Province, China. Women (44408) on COC user and 75230 women with an intrauterine device (IUD) were followed up for the incidence of stroke. Th e incident cases of stroke (including cerebral infarction, cerebral hemorrhage and subarachnoid hemorrhage) identifi ed by computerized tomography (CT) or nuclear magnetic resonance (NMR). Two diff erent controls including hospitalized patients and neighborhood were matched to the cases according to age ±3 years; residence and similar date of admission for hospitalized patients. Body weight, height, waist circumference (WC), blood pressure, serum lipids and apolipoproteins were measured. Polymerase chain reaction (PCR) was used to amplify polymorphic gene regions for the genotyping of ACE I/D and ACE 2350. Th e primers and enzyme of AGTA-20C were designed by the PIRA PCR method. Genotyping of 3 SNPs (rs700651, rs10958409 and rs1333040) was performed by the polymerase chain reaction assay with TaqMan probes. Results: Th ere is an increased risk of haemorrhagic stroke among Chinese users of long-term low-dose oral contraceptives which appears to persist long aft er discontinuation. Th e risk of hypertension gradually increased with the increasing cumulative time of COC use in women (P=0.0043), dyslipidaemia, accumulative time of COC use ≥15 years and their interaction increased the risk of hypertension. Hypertension was a most important risk factor for stroke incidence. Th e D allele of ACEI/D polymorphism may be a potential risk allele for stroke. COC users carried the ID+DD genotype that may further increase the risk of stroke especially for hemorrhagic stroke. Our results confi rmed the associations of two GWAS SNPs (rs10958409 and rs1333040), moreover, the risk of hemorrhagic stroke increased by 4.81 and 15.06-folds when risk allele carriers of rs10958409 or rs1333040 who took COC. Th e study assessed the associations of three PAI-1 SNPs and also suggested combined eff ects of these PAI-1 gene variants and COC use on stroke risk in the Han Chinese women. Conclusions: Th e research results have promoted the understanding of the important high risk factors of Chinese female stroke and provide evidence to formulate proper prevention measures for coping with the challenges of and an increased incidence of female stroke.

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