B. Longo-Mbenza
Walter Sisulu University, South Africa
Title: Exposome, Aging, infections, Climate change and variability, and biomarkers of infl ation, immune dysfunction, endothelial dysfunction, oxidative stress, and thrombo-embolism for Stroke in Sub- Saharan Africa
Biography
Biography: B. Longo-Mbenza
Abstract
Lessons learnt within 34 years in Sub-Saharan Africa highlight the impacts of genetic factors (plague, ethnicity, sickle cell disease) and exposure to environmental factors (seasons, climate change and variability), host attributes (male gender and age), traditional risk factors (hypertension, diabetes, tobacco, heavy alcohol used and dyslipidemia), infections (HIV, Helicobacter pylori and chlamydia pneumoniae), biomarkers of auto-immunity, infl ammation (fi brinogen and BMP), oxidative stress (oxidized LDL), elevated uric-acid, elevated hematocrit and hemostasis (D dimer) on incident stroke types and mortality. Hypolipemia, younger age, and uncontrolled hypertension are associated with hemorrhagic strokes whereas hyperlipemia, older age, poverty, diabetes, HIV, Helicobacter Pylori, El Nino and sickle cell disease are associated with ischemic strokes and high mortality.