Neurological Disorders and Stroke

Biography

Biography: Oleksandr Makarenko

Abstract

Investigation of pharmacological activity of brain Trophinotropic factors, that formed in brain cells is very actual. Receiving from female pigs after brain's hemorrhagic stroke recovery, medicine "Cerebral" is a peptide trophinotropines with brain protective, regulative, activative and modulative actions. Trophinotropine "Cerebral" was protected of the active zones of the axodendritic synapses. Destruction dendrites system of the microtubules in the pleximorph area of sensomotoric cerebrocortex are not so often registered in trophinotropine treated animals. It was shown, that "Cerebral" administrations (0,01 - 0,02 mg/kg bow., imp., twice with the interval of day) to cats with experimental model of hemorrhagic stroke was accompanied with 70% decrease of mortality, reduced symptoms of the disease: recovered of limbs movements decreases of coordination disturbances, and normalization of some reflexes. Under conditions of chronic emotional stress (15 days) "Cerebral" (0,1 mg/kg b.w., i.p., before and on the 9h day of stress exposure) prevented the decrease of rats body weight, reduced the concentration of initial and intermediate products of lipid peroxidation, normalized the activity of antioxidant enzymes (SOD and catalase) in hypothalamus and cerebrocortex zones. "Cerebral" normalized spleen cytological parameters and blood neitrophils cytochemical reactions. Trophinotropine accelerates progress of structural and functional restoration of alterative neurons (activities effect), have a cytoprotective and different pharmacological properties-trigger and contrapoptotic actions in early post stroke period. This medicine was suggested for treatment of sharp periods of stroke and decompensation phases of disease have had an original medicinal form (nasal drops), which essentially, will simplify treatment patients.