Makarenko O.M. has taken PhD degree at the age of 30 at the Moscow medical stomatological institute, M.D. degree at the age of 40 at the Institute of higher nervous activity in Moscow. He carries out his post-dock researches at the Institute of higher nervous activity and T. G. Shevchenko national university of Kiev. He is a professor of the psychology department, the author of more than 100 articles in reputed journals and 4 monographs (Lambert Academic Publishing).

Mitochondrin (M2) and Cerebral is a complex of trophinotropic regulatory oligopeptides, polypeptides and amino acids. These medicines have antihypoxic, trophinotropic and rehabilitation properties. Experiments were conducted with 40 white pubescent male rats in the acute period of the simulated hemorrhagic stroke (HS). Within 10 days after modeling different groups of animals were injected with M2 (intraperitoneal, 0.1 mg/kg/days) and Cerebral (intranasal, 0.15 mg/kg/ days). Glial analyses of the sites of the sensomotor cerebrum cortex of the ipsilateral hemisphere was held: Glial Formula (GF) (the quantitative (%) content of glial cells of the total gliocytes and neurons (GF=astrocytes (A)+oligodendrocytes (O)+microgliocytes (M)) Glial Index Quantitative (GIQ) (a ratio of one type of gliocytes to another: GIQ1=A/M, GIQ2=O/M, GIQ3=A/O). In comparison with values before the use of M2, this medicine increased the amount of astrocytes (on 43.91%), ependymocytes (on 32.9%), reduced the amount of microgliocytes (on 35.1%) and has not have any positive effect on the oligodendrocytes; increased the rate of GIQ1 (on 62.4%), GIQ3 (on 67%) and reduced GIQ2 (on 15.99%). Cerebral authentically did not restore on the quantity of astrocytes, oligodendrocytes, microgliocytes and ependymocytes. Cerebral signifi cantly reduced GIQ1 (on 40.07%) and GIQ2 (on 22.6%). The partial positive infl uence of the offered agents for correction of glio-glial interrelations in the sensomotor cerebral cortex of rats in the acute period of HS has been revealed.

Monica Rincon completed her Medical School in 1989 from Universidad El Bosque, Colombia. She has specialized in Physical Medicine and Rehabilitation from Universidad El Bosque Colombia in 1994, she also had training in Cardiac and Pulmonary Rehabilitation from Alton Ocshner Foundation New Orleans Louisiana. She has completed her Master’s degree in Bioethics (2004) from Katholieke Universieit Leuven; Belgium and a Master degree in Physiology from Universidad Nacional de Colombia in 2011. She is the Director of Rehabilitation Service, Fundación Cardioinfantil-Institute of Cardiology, Professor in the Faculty of Medicine at Universidad del Rosario and Universidad de La Sabana. She has published papers in different journals and has been serving as an Editorial Board Member (Revista Colombiana de Cardiología and Revista Colombiana de Medicina Física y Rehabilitación).

The National Health Observatory of the National Institute of Health in Colombia states that cardiovascular diseases are the leading cause of death in the country. In the period 1998-2011, 628-630 deaths from cardiovascular disease were reported corresponding to 23.5% of all deaths in Colombia. Of the deaths attributed to the group of selected cardiovascular disease, 56.3% were due to ischemic heart disease, 30.6% to cerebrovascular disease, 12.4% to hypertensive disease and 0.5% to chronic rheumatic heart disease. Many studies have established that stroke is the leading cause of neurological disability in adults and that the poor level of fi tness including a low functional capacity are the factors limiting patients to make their daily life activities and impact the risk of a new episode and increase mortality from this cause. This decrease in functional capacity has negative effects on mobility and resistance to fatigue and further worsens its functional performance and independence leading to greater restriction of their participation in the community. Similarly, it is known that about 75% of stroke patients have heart disease sharing the same risk factors and the cardiovascular disease is the major factor that limits the successful results in rehabilitation after a stroke. This demonstrates the existence of a close relationship between coronary heart disease and cerebrovascular event in terms of etiology associated diseases and risk factors which in turn suggests that strategies that have been used successfully for the treatment of coronary disease may be useful for the management of this condition. The cardiovascular and respiratory training provided by the programs of Cardiac Prevention and Rehabilitation reduces fatigue, incidence of falls and fractures while providing better compensation of energy cost of hemiparetic gait. Similarly, reduces disability by its impact on mobility, body balance and balance among others. Patients with this type of training improve functional independence, their perceived quality of life and mood. Various studies have shown how patients admitted to programs of cardiac prevention and rehabilitation have signifi cant clinical improvement in participation in activities of daily living perceived through the stroke impact scale. This participation which results in community integration is the main predictor of the overall recovery of a disabled person. Thus, cardiac prevention and rehabilitation programs offer an opportunity to reduce cardiovascular risk, mortality and recurrence of stroke and have also shown to improve the perceived quality of life due to provided components of exercise and education. Therefore, the current proposal is to consider the model of cardiac rehabilitation as a secondary prevention strategy in stroke care because it has shown a signifi cant positive impact in reducing morbidity and mortality by achieving one of the most important objectives in the treatment of these patients-The marked improvement in the perception of their quality of life.