Day 2 :
Keynote Forum
Mojtaba ehsanifar
Dr. Mojtaba Ehsanifar has completed his Ph.D. from the Iran University of Medical Sciences
Keynote: Exposure to ambient ultra-fine particles and stroke
Time : 2.45pm
Biography:
Dr. Mojtaba Ehsanifar has completed his Ph.D. from the Iran University of Medical Sciences, Tehran, Iran. And now he continues his research on environmental Neuroscience, Neurotoxicology and Environmental Exposome as a postdoc student. His research interests include Neurotoxicology, Neurobehavioral, Neuroinflammation, and Oxidative Stress.
Abstract:
Stroke is one of the main causes of death attributed to air pollution. Significant research has now shown that urban air pollutants exposure has been established as a source of neuroinflammation and oxidative stress that causes central nervous system (CNS) disease. Transition metals, particulate matter (PM) including fine particles (PM ≤ 2.5μm, PM 2.5) and ultra-fine particles (UFPs, PM <0.1μm, PM 0.1), nitrogen oxide, and ozone are potent or oxidant that capable of producing reactive oxygen species (ROS) can reach the brain and affect CNS health. Numerous biological mechanisms are responsible that are not well understood. Recent studies suggest that changes in the blood-brain barrier (BBB) and or leakage and transmission along the olfactory nerve into the olfactory bulb (OB) and microglial activation are the key factors of CNS damage following exposure to air pollution. This preliminary review cites evidence that ambient PM exposure is one of the causes of stroke.
Keynote Forum
Andreadou Eleni
Andreadou Eleni
Keynote: Bacterial DING proteins in Alzheimer’s disease and Mild Cognitive Impairment and correlation with Αβ-42 and COX-1/2
Biography:
Dr Andreadou Eleni obtained a PhD in Biochemistry at the Biochemistry Laboratory of Chemical Department of Aristotle University of Thessaloniki. She is quite experienced on various research topics including Alzheimer’s disease. She has participated in 5 research programs and she has 11 publications in international journals and 13 participations in conferences
Abstract:
Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI) have been linked to inflammation as their pathology is partially attributed to common bacterial infections, while the enormous economic burden of dementia imposes the discovery of new biomarkers in biological fluids other than cerebrospinal fluid (CSF). DING proteins identified mainly by their N-terminal sequences are common in Pseudomonas, have potential roles in phosphate acquisition and pathogenicity and they have been implicated with many human diseases. The aim of this research was to investigate the levels of the bacterial DING proteins in blood serum and their correlation with the neurodegeneration markers Αβ42 and tau and the inflammation markers COX-1 and COX-2. Levels of DING were measured with indirect ELISA in blood serum of AD (N=18) and MCI patients (N=23) in comparison with cognitive healthy individuals (N=13). The biomarkers of inflammation COX-1 and COX-2, and the established in CSF AD biomarkers, Αβ42 and tau, were measured as well. DING levels were found significantly increased in serum of AD patients in comparison with cognitive healthy subjects and MCI patients. Serum DING proteins positively correlate with Αβ42, COX-1 and especially with COX-2 levels. Also, serum DING levels negatively correlate with the mental state of patients. Multi-linear regression analysis proves that DING levels in serum are significantly determined by the mental state of patients and COX-2 levels, as well as the age of patients. AUC analysis proves that serum DING could be used as a possible biomarker in serum to discriminate AD patients from both cognitive healthy individuals and especially MCI patients